Depends on how they're writing the humans. Cyberverse is a good example of their being no actual reason to ever have gone to Earth in the first place aside from cause the plot said so, they don't ever actually mingle with a human onscreen. Thankfully they decided to leave earth in the second season, if you're not really gonna bother with humans, just don't go to earth in the first place.
More Cybertron stories would be awesome especially if Bayverse continued so we could see rebuilding of Cybertron.
I like a mix, mainly because the Earth can introduce some excellent plot devices like the Cybertronian Prison in TF Cybertron and the Predacon Graveyard in TF Prime. I don't feel a whole series should stay there though, my favourite balance of setting was in TF Cybertron.
True true but on Earth,in mostly of the episodes I'd relegate humans to background role, I'd choose more Earth for different environments as big human instalallations or many different landscapes as skies ,forests and like this, that is very fitting.
If he's are just going to be in the background than you might as well not have them there at all or set it on another Earth like planet. Now the Humans that get involved should be well known characters, like Spike or Cobra Commander.