I've heard that the Lizard will be a complicated villain in the movie. He will go through a character transformation like Spiderman. Also the "Ready to play God" line in the trailer kinda screams Jekyll and Hyde/Frankenstein type character to me. He tries create something good, but he instead creates a monster. I predict that he'll outsmart a bunch of cops in the movie and kill them. That will create the need for Spiderman to intervene.