I'm waiting on the Smurfs crossover, where we find out smurfs are a great source of energon. Also, I feel like Smurfette and Arcee would have a lot to talk about, what with their equally creepy origin stories.
Hell, in a single fantasy world that has TF, GI Joe, Mask, Micronauts, is it really much worse to throw in Wheeled Warriors, MLP, In humanoids, and PEZ? What's one more withdrawal when you're already creatively bankrupt?
How does the quality of the 80s show have any relation to a modern IDW reboot, if such a thing were possible?
This particular show does not relate with Transformers. Jayce and his team basically fight plants if the setting was Earth and no robots yeah I can see them doing it.
So The Lost Light would have run-ins with Jayce and the Monster Minds in space instead of Jayce coming to Earth or Cybertron.
That would work if Jayce is a fringe element of the Galactic Council. Monster Minds will be anti-mechanical lifeforms and tech and are terrorist to bring back purity of organic life which is plants.
If there was ever a property in need of a continuation,,,, I could go either way, new episodes, a more mature filling out of unanswered questions (and a showdown with the Queen) or a next gen series, say with Little Zac being the new Comander Walsh 30 years later. IIRC, it wasn't that bad a show. They were pigeon holed into making the vehicles part of the show of course, but they did their best to make some interesting if not exactly original characters. (Although I could be mis remembering some Ulyssies episodes too. There was a similar show on around the same time)
Not in the IDW continuities, but they've appeared in Collector Club fiction such as Ask Vector Prime. The tfwiki folks catalog their continuity as Xobitor reality stream, in which those characters are a version of the Transformers. I know some fans don't consider As Vector Prime to be canon - I enjoyed it, but your results may vary.