Imagine Spider-Man reinventing itself the way the UT "reinvented" Transformers: -Spider-Man/Peter Parker himself would remain largely similar, but maybe he's from Chicago now instead of New York. -Mary Jane would be Peter's longtime best friend who's extremely unattractive and they never end up dating. She gets to keep the red hair though. -J. Jonah Jameson won't exist since newspapers are hard. -Dr. Octopus will be a literal mutant octopus. -Venom would be a drug dealer with no powers. -Kingpin would be a bowling-themed gimmick villain.