Is this even possible, because the comic panel would be an actual image? I didn't think so, but just to be sure, I tried with the two I use (they're free). They did not work. If anyone uses a TTS (if you bought it, can you tell me how much it was and how satisfied you are with it?). I only really use them when I'm reading fanfiction or something lengthy, but thought, 'wouldn't it be great if I could use these on comics, too?' Some of the words way too small to make out without having to squint and pull out magnifying glasses--especially on the computer screen. If I've confused you--don't worry, I'm confused too. In fact, that's how I spend 70% of my day. Just run along, lol.