There are at least 5 instances in the Marvel Comics, IIRC 1) Sparkplug WItwicky spike the Decepticon's energon with a freakin' powerful corrosive that left them crippled while fighting the Autobots. Only Shockwave's timely intervention saved them from defeat. 2)Shockwave, while assaulting a G.B. Blackrock oil rig, got harpoons stuck inside his skin. 3)Sephie Beller covered herself in circuits and became a robot-zapping supervillain. 4)G.B. Blackrock commissioned a squad of super heroes with one purpose : To fight Decepticons. 5) Megatron was injured by a Cobra-made Railgun, and was so impressed with it's power he traded his fusion cannon for one.. That's right! Megatron ditched his Cybertronian tech for a lowly human weapon. But for some inexplicable reasons (yeah, right!), Michael Bay is the first person to commit such a heinous crime against transfandom.