It can be canon, and basically it would be about NEST with the Autobots fighting Cons around the world. Just like Star Wars: The Clone wars, in which each episode was about a Jedi with some clones fighting droids and Greivous, something similair could be done with Transformers. Each episode will involve the Bots fighting in missions. They can focus on a specific Autobot, to give him more characterisation (like Sideswipe or Jolt). A few episodes can be about Sam and BB. Or, they can do a 2 hour animated movie like Batman: the Gotham Knight (only this will not be Anime and it will be only one story, of course).